Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4

Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4

Abstract The breakdown of Golgi proteins disrupts lipid trafficking, leading to lipid accumulation in the small intestine. However, the causal mechanism of the effects of Golgi protein degradation on the Golgi structure related to lipid trafficking in the small intestine remains unknown. Here we fin...

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Main Authors: Hyunsoo Kim, Channy Park, Xiaofan Wei, Arun Chhetri, Laxman Manandhar, Gyuho Jang, Jaetaek Hwang, Batchingis Chinbold, Chagtsalmaa Chuluunbaatar, Hyug Moo Kwon, Raekil Park
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01396-2
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https://doi.org/10.1038/s12276-025-01396-2

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