DNA methylation protects cancer cells against senescence

DNA methylation protects cancer cells against senescence

Abstract Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challenging to discern their respective effects. Here we d...

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Main Authors: Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goehrig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Sophie Lanciano, Nadine Martin, Pierre Dubus, Fumihito Miura, Takashi Ito, Gael Cristofari, Nicolas Manel, Masato T. Kanemaki, David Bernard, Pierre-Antoine Defossez
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61157-7
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https://doi.org/10.1038/s41467-025-61157-7

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