Assessment of Food Effect and pH‐Dependent Drug–Drug Interactions of Fruquintinib in Healthy Subjects

Assessment of Food Effect and pH‐Dependent Drug–Drug Interactions of Fruquintinib in Healthy Subjects

ABSTRACT This two‐sequence, three‐period study (NCT04645940) was designed to evaluate the effect of food and concomitant rabeprazole, a proton pump inhibitor, on the pharmacokinetics (PK) and safety of fruquintinib and its metabolite M11 after a single oral dose of fruquintinib 5 mg in healthy subje...

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Bibliographic Details
Main Authors: Martha Gonzalez, Zhao Yang, William R. Schelman, Xiaofei Zhou, Neeraj Gupta, Caly Chien
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Science
Subjects:
drug–drug interaction
fruquintinib
pH reducing
pharmacokinetics
proton pump inhibitor
rabeprazole
Online Access:https://doi.org/10.1111/cts.70168
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