Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic

Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic

BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refractory melanoma patients. We sought to evaluate the anti-t...

Full description

Saved in:
Bibliographic Details
Main Authors: Maite Alvarez, Carmen Molina, Saray Garasa, Maria C. Ochoa, Maria E Rodriguez-Ruiz, Gabriel Gomis, Assunta Cirella, Irene Olivera, Javier Glez-Vaz, Jose Gonzalez-Gomariz, carlos luri-Rey, arantza azpilikueta, Elixabet Bolaños, Alvaro Teijeira, Pedro Berraondo, Marisol Quintero, Ignacio Melero
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
BO-112
intratumoral immunotherapy
metastases
neoadjuvant
PD-1
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2197370
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2023.2197370

Similar Items