Asymmetrical reliability of the Alda score favours a dichotomous representation of lithium responsiveness.

Asymmetrical reliability of the Alda score favours a dichotomous representation of lithium responsiveness.

The Alda score is commonly used to quantify lithium responsiveness in bipolar disorder. Most often, this score is dichotomized into "responder" and "non-responder" categories, respectively. This practice is often criticized as inappropriate, since continuous variables are thought...

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Bibliographic Details
Main Authors: Abraham Nunes, Thomas Trappenberg, Martin Alda, international Consortium on Lithium Genetics (ConLiGen)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0225353/1/pone.0225353.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210219%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210219T103322Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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