Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation

Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation

Abstract This study investigates the inhibitory potential of four glucosinolates—glucoerucin, glucoiberin, gluconasturtiin, and glucotropaeolin—isolated from watercress (Nasturtium officinale) against Protein Tyrosine Phosphatase 1B (PTP1B), a key regulator of insulin signaling. Molecular docking, m...

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Main Authors: Noha A. Ahmed, Ahmed A. Allam, Hassan A. Rudayni, Fahad M. Alshabrmi, Faris F. Aba Alkhayl, Doaa A. Abdelrheem, Al Mokhtar Lamsabhi, Sarah I. Othman, Emadeldin M. Kamel
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Chemistry
Subjects:
Watercress
PTP1B
Glucosinolates
In silico
In vitro
Online Access:https://doi.org/10.1186/s13065-025-01544-9
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https://doi.org/10.1186/s13065-025-01544-9

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