Single-cell multi-omics-based immune temporal network resolution in sepsis: unravelling molecular mechanisms and precise therapeutic targets

BackgroundSepsis is the leading cause of death globally (49 million cases per year with a 25-30% morbidity and mortality rate), but its immunopathology remains incompletely elucidated. Conventional models of ‘uncontrolled inflammation’ fail to explain the diversity of immune status in patients at di...

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Bibliographic Details
Main Authors: Han Liu, Qun Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616794/full
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