Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses

Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses

Abstract Background The “psychedelic renaissance” is sparking growing interest in clinical research, along with a rise in clinical trials. Substances such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin and N,N-dimethyltryptamine (DMT) are involved. The focus of this paper is on indolethylam...

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Main Authors: Matteo Ardini, Francesco Angelucci, Francesca Rea, Luca Paluzzi, Federica Gabriele, Marta Palerma, Luana Di Leandro, Rodolfo Ippoliti, Giuseppina Pitari
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Biology Direct
Subjects:
Psychedelic
Indolethylamine N-methyltransferase assay
Quinoline
S-adenosylmethionine
Online Access:https://doi.org/10.1186/s13062-025-00632-z
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https://doi.org/10.1186/s13062-025-00632-z

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