The HNRNPC/CELF2 signaling pathway drives glycolytic reprogramming and mitochondrial dysfunction in drug-resistant acute myeloid leukemia

The HNRNPC/CELF2 signaling pathway drives glycolytic reprogramming and mitochondrial dysfunction in drug-resistant acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) is an aggressive cancer with high treatment resistance, often leading to poor patient outcomes. Metabolic reprogramming plays a critical role in AML progression, influencing drug resistance (DR) and tumor survival. This study investigates the HNRNPC/C...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiang Ma, Haodong Li, Ziqi Zhao, Changchun Li, Man Wang, Lele Zhang, Yutong Zhao, Haipeng Su, Feng Wang, Jiai Hua
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell & Bioscience
Subjects:
Acute myeloid leukemia
Heterogeneous nuclear ribonucleoprotein C
CUGBP elav-like family member 2
Glucose metabolism reprogramming
Drug resistance
Cell migration
Online Access:https://doi.org/10.1186/s13578-025-01386-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13578-025-01386-x

Similar Items