Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations]
Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental ef...
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| Format: | Article |
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F1000 Research Ltd
2024-12-01
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| Online Access: | https://f1000research.com/articles/12-1265/v2 |
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| author | Madhu Dyavaiah Chella Perumal Palanisamy Tewin Tencomnao Siriporn Chuchawankul Phaniendra Alugoju Naga Venkata Anusha Anthikapalli Anchalee Prasanskulab Selvaraj Jayaraman |
| author_facet | Madhu Dyavaiah Chella Perumal Palanisamy Tewin Tencomnao Siriporn Chuchawankul Phaniendra Alugoju Naga Venkata Anusha Anthikapalli Anchalee Prasanskulab Selvaraj Jayaraman |
| author_sort | Madhu Dyavaiah |
| collection | DOAJ |
| description | Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast Saccharomyces cerevisiae has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging S. cerevisiae has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS). This review explores the anti-aging properties of natural products, predominantly derived from plants, and phytoextracts using S. cerevisiae as a model organism. |
| format | Article |
| id | doaj-art-44bf79fe93b04655a0108d59f2c6df8d |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-44bf79fe93b04655a0108d59f2c6df8d2025-01-16T01:00:01ZengF1000 Research LtdF1000Research2046-14022024-12-0112175742Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations]Madhu Dyavaiah0Chella Perumal Palanisamy1https://orcid.org/0000-0002-3527-3477Tewin Tencomnao2https://orcid.org/0000-0003-4177-2165Siriporn Chuchawankul3https://orcid.org/0000-0002-7627-0408Phaniendra Alugoju4Naga Venkata Anusha Anthikapalli5Anchalee Prasanskulab6https://orcid.org/0000-0001-8884-3077Selvaraj Jayaraman7Department of Biochemistry and Molecular Biology, Pondicherry University (A Central University), Puducherry, 605 014, IndiaDepartment of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, ThailandDepartment of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandDepartment of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandDepartment of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandDepartment of Chemistry, A.N.R College, Gudivada, Andhra Pradesh, 521301, IndiaCollege of Public Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, Tamilnadu, 600077, IndiaHistorically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast Saccharomyces cerevisiae has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging S. cerevisiae has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS). This review explores the anti-aging properties of natural products, predominantly derived from plants, and phytoextracts using S. cerevisiae as a model organism.https://f1000research.com/articles/12-1265/v2Saccharomyces cerevisiae Replicative lifespan (RLS) Chronological lifespan (CLS) nutrient signalling pathways target of rapamycin (TOR) Protein kinase A (PKA)eng |
| spellingShingle | Madhu Dyavaiah Chella Perumal Palanisamy Tewin Tencomnao Siriporn Chuchawankul Phaniendra Alugoju Naga Venkata Anusha Anthikapalli Anchalee Prasanskulab Selvaraj Jayaraman Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research Saccharomyces cerevisiae Replicative lifespan (RLS) Chronological lifespan (CLS) nutrient signalling pathways target of rapamycin (TOR) Protein kinase A (PKA) eng |
| title | Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | exploring the anti aging potential of natural products and plant extracts in budding yeast saccharomyces cerevisiae a review version 2 peer review 1 approved 2 approved with reservations |
| topic | Saccharomyces cerevisiae Replicative lifespan (RLS) Chronological lifespan (CLS) nutrient signalling pathways target of rapamycin (TOR) Protein kinase A (PKA) eng |
| url | https://f1000research.com/articles/12-1265/v2 |
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