Determination of residual alkyl iodides and alkyl bromides as their corresponding alkyl chlorides in drug substances by headspace GC-FID

Determination of residual alkyl iodides and alkyl bromides as their corresponding alkyl chlorides in drug substances by headspace GC-FID

Primary and secondary alkyl iodides and primary alkyl bromides were quickly and conveniently converted into their corresponding alkyl chlorides via SN2 halide-halide substitution. The resultant alkyl chlorides simultaneously demonstrated increased volatility and stability paired with standard headsp...

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Bibliographic Details
Main Author: Brian T. Zielke II
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Alkyl halide
Iodomethane
Drug substance
Derivatization
Headspace-GC
Methyl iodide
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024170491
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