A polygenic risk score model for psoriasis based on the protein interactions of psoriasis susceptibility loci

A polygenic risk score model for psoriasis based on the protein interactions of psoriasis susceptibility loci

IntroductionPolygenic Risk Scores (PRS) are an emerging tool for predicting an individual’s genetic risk to a complex trait. Several methods have been proposed to construct and calculate these scores. Here, we develop a biologically driven PRS using the UK BioBank cohort through validated protein in...

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Bibliographic Details
Main Authors: Charalabos Antonatos, Fotios Koskeridis, Christiana M. Ralliou, Evangelos Evangelou, Katerina Grafanaki, Sophia Georgiou, Konstantinos K. Tsilidis, Ioanna Tzoulaki, Yiannis Vasilopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Genetics
Subjects:
psoriasis
polygenic risk score
protein-protein interaction
genome-wide association study
risk prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1451679/full
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https://www.frontiersin.org/articles/10.3389/fgene.2024.1451679/full

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