Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

Abstract Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynamics, is an alternative method to anticipate drug r...

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Main Authors: Elizabeth G. Fernandez, Wilson X. Mai, Kai Song, Nicholas A. Bayley, Jiyoon Kim, Henan Zhu, Marissa Pioso, Pauline Young, Cassidy L. Andrasz, Dimitri Cadet, Linda M. Liau, Gang Li, William H. Yong, Fausto J. Rodriguez, Scott J. Dixon, Andrew J. Souers, Jingyi Jessica Li, Thomas G. Graeber, Timothy F. Cloughesy, David A. Nathanson
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54138-9
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https://doi.org/10.1038/s41467-024-54138-9

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