Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification

Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification

During lung cancer metastasis, tumor cells undergo epithelial-to-mesenchymal transition (EMT), enabling them to intravasate through the vascular barrier and enter the circulation before colonizing secondary sites. Here, a human in vitro microphysiological model of EMT-driven lung cancer intravasatio...

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Bibliographic Details
Main Authors: Christy Wing Tung Wong, Joyce Zhi Xuen Lee, Anna Jaeschke, Sammi Sze Ying Ng, Kwok Keung Lit, Ho-Ying Wan, Caroline Kniebs, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Bioactive Materials
Subjects:
Cancer intravasation
Lung cancer
Epithelial-to-mesenchymal transition (EMT)
Macrophages
Transforming growth factor-beta 1 (TGF-β1)
Microfluidic devices
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002567
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