Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease

Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease

ObjectivePeripheral helper T (Tph) cells, together with plasma cells, are the major pathogenic lymphocytes in the synovium in rheumatoid arthritis (RA). However, whether these cells are involved in RA-associated lung and/or airway disease is unknown.MethodsTph cells in sputum were analyzed by flow c...

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Main Authors: Eito Yokoi, Keiko Wakahara, Saya Nakamura, Eriko Fukutani, Shuji Asai, Nobunori Takahashi, Toshihisa Kojima, Shingo Iwano, Satoko Shimada, Toyofumi Fengshi Chen-Yoshikawa, Naozumi Hashimoto, Makoto Ishii
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
peripheral helper T cells
sputum
lung tissue
airway disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526881/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526881/full

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