Discovery and Optimization of Ergosterol Peroxide Derivatives as Novel Glutaminase 1 Inhibitors for the Treatment of Triple-Negative Breast Cancer

Discovery and Optimization of Ergosterol Peroxide Derivatives as Novel Glutaminase 1 Inhibitors for the Treatment of Triple-Negative Breast Cancer

In this study, novel ergosterol peroxide (EP) derivatives were synthesized and evaluated to assess their antiproliferative activity against four human cancer cell lines (A549, HepG2, MCF-7, and MDA-MB-231). Compound <b>3g</b> exhibited the most potent antiproliferative activity, with an...

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Bibliographic Details
Main Authors: Ran Luo, Haoyi Zhao, Siqi Deng, Jiale Wu, Haijun Wang, Xiaoshan Guo, Cuicui Han, Wenkang Ren, Yinglong Han, Jianwen Zhou, Yu Lin, Ming Bu
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Molecules
Subjects:
ergosterol peroxide derivatives
GLS1 inhibitors
antitumor
TNBC
Online Access:https://www.mdpi.com/1420-3049/29/18/4375
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