Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation

Abstract Orderly development of neuroendocrine and nervous system of mammals requires INSM1, a key regulator for cell differentiation. Ectopic expression of INSM1 is closely correlated with human neuroendocrine tumorigenesis, which makes INSM1 a reliable diagnostic biomarker and potential therapeuti...

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Bibliographic Details
Main Authors: Heng Zhou, Xiaoling He, Yue Xiong, Yixuan Gong, Yuanyuan Zhang, Shuangli Li, Rui Hu, Ying Li, Xu Zhang, Xin Zhou, Jiang Zhu, Yunhuang Yang, Maili Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57478-2
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