Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune condition that impacts various organs. Given the intricate clinical progression of SLE, it is imperative to explore novel avenues for precise diagnosis and treatment.MethodsPeripheral blood mononuclear cells (PBMC) were isolated from 6 SL...

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Bibliographic Details
Main Authors: Jingjing Zhang, Ling Ma, Hanyin Deng, Wenqian Yi, Alim Tohtihan, Xiaojun Tang, Xiudi Wu, Xuebing Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
ATAC-seq
RNA-Seq
NK cells
open chromatin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1580540/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1580540/full

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