APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly

APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly

Abstract The ε4 allele of the Apolipoprotein E (APOE) gene is an important genetic risk factor for several neurodegenerative diseases, while the common pathogenic mechanism is still unclear. Impaired synaptic transmission is one of the common pathogenic features of neurodegenerative diseases. By usi...

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Main Authors: Feng Chen, Yanting Chen, Sifan Feng, Huiyi Chen, Liehua Deng, Fubin Ma, Qiongwei Ke, Qiuhao Liang, Ji Chen, Xiaoping Peng, Jiongtong Lu, Yingxuan Liu, Yuying Xie, Hao Cao, Yuanhong Sun, Wenxian Wu, Lili Cui, Yan Wang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
APOE4
VAMP2
SNARE complex
Synaptic function
Alzheimer’s disease
Online Access:https://doi.org/10.1007/s00018-025-05787-6
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https://doi.org/10.1007/s00018-025-05787-6

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