Efficient statistical analysis of trial designs: win ratio and related approaches for composite outcomes

Abstract In randomized controlled clinical trials, composite outcomes are often used to study treatment effects. This approach is popular because it increases the number of observed events, enhancing statistical power while reducing the required patient sample size. However, composite outcomes do no...

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Bibliographic Details
Main Authors: Wilson Fandino, Matthew Dodd, Gudrun Kunst, Tim Clayton
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Perioperative Medicine
Online Access:https://doi.org/10.1186/s13741-025-00550-8
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