Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

Abstract Schizophrenia is a neuropsychiatric disorder with heritability estimates between 60% and 80%. Although genome-wide association studies have identified many genetic loci linked to the disorder, most of these are noncoding variants whose functional impacts are not well understood. To bridge t...

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Main Authors: Chengwen Gao, Qian Zhang, Chuanhong Wu, Lixia Peng, Mingxuan Wu, Baokun Wang, Baiqiang Xue, Mingming Niu, Yajie Jiang, Wenli Yuan, Haiyan Song, Xiangyu Li, Xiangzhong Zhao, Yujuan Niu, Yuanchao Sun, Yonghe Ding, Zhiqiang Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08456-3
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https://doi.org/10.1038/s42003-025-08456-3

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