Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma

Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma

Abstract Background The efficacy of immune checkpoint blockade therapy in patients with hepatocellular carcinoma (HCC) remains poor. Although serine‐ and arginine‐rich splicing factor (SRSF) family members play crucial roles in tumors, their impact on tumor immunology remains unclear. This study aim...

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Main Authors: Jialiang Cai, Lina Song, Feng Zhang, Suiyi Wu, Guiqi Zhu, Peiling Zhang, Shiping Chen, Junxian Du, Biao Wang, Yufan Cai, Yi Yang, Jinglei Wan, Jian Zhou, Jia Fan, Zhi Dai
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Cancer Communications
Subjects:
Glycolysis
Histone lactylation
Immune checkpoint blockade
Serine and arginine rich splicing factor 10
Tumor‐Associated Macrophage
Online Access:https://doi.org/10.1002/cac2.12607
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https://doi.org/10.1002/cac2.12607

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