Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8

Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8

Abstract Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule interacting and trafficking) domain, followed by a non-catalytic rhodanese (Rhod) domain, a long...

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Main Authors: Aimiliani Konstantinou, Julia K. Varga, Alicia Córdova-Pérez, Leandro Simonetti, Lidia Gomez-Lucas, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu, Ylva Ivarsson
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biology Direct
Subjects:
USP8
MIT domain
Rhodanese domain
SLiMs
Peptide-phage display
Deep mutational scanning
Online Access:https://doi.org/10.1186/s13062-025-00638-7
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https://doi.org/10.1186/s13062-025-00638-7

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