Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the absence of cells from the tumor microenvironment, thereby prohibiting potential investigation of tr...

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Main Authors: Johannes Laengle, Julijan Kabiljo, Jakob Homola, Gerda Egger, Michael Bergmann, Wolfgang Weninger, Matthias Farlik, Askin Kulu, Anna Theophil, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver Pusch, Henning Walczak, Dietmar Herndler Brandstetter, Helmut Dolznig, Anna Kusienicka
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009494.full
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