Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis

Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis

Abstract Background and aim Generation of functional cardiomyocytes from human pluripotent stem cells (hPSCs) offers promising applications for cardiac regenerative medicine. Proper control of pluripotency and differentiation is vital for generating high-quality cardiomyocytes and repairing damaged...

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Bibliographic Details
Main Authors: Ying Wang, Yang Cui, Xiaoyu Liu, Shengxian Liang, Li Zhong, Rui Guo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cell
Cathepsin K
Cardiomyocyte differentiation
Energy metabolism
Mitochondrion
Lysosome
Online Access:https://doi.org/10.1186/s13287-025-04231-7
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https://doi.org/10.1186/s13287-025-04231-7

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