POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma

POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma

Segmental chromosomal alterations, including 11q deletion and 17q gain, are the strongest predictors of pediatric neuroblastoma relapse. These alterations result from unbalanced translocations linked to erroneous DNA repair. Breakpoint sequence analysis suggests that these abnormalities arise throug...

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Bibliographic Details
Main Authors: Sahiti Chukkapalli, Keyonna Williams, Biao Hu, Kimber Converso-Baran, Olivia Tussing, Patrick O'Brien, Nouri Neamati, Erika A. Newman
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
DNA repair
POLQ
Neuroblastoma
Therapy resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001640
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