Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in “double-hit” mice

Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in “double-hit” mice

Abstract Background This study investigates the complex interplay between gut microbiome dysbiosis and systemic inflammation as a critical risk factor in the pathogenesis of osteoarthritis (OA). Furthermore, it elucidates the role of gut microbiota (GMB) dysbiosis in driving OA progression. Methods...

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Bibliographic Details
Main Authors: Su Liu, Huihui Xu, Lijin Liu, Wenjing Ma, Hao Fan, Fei Liu, Ze Wei, Jing Hao, Zhifa Zheng, Lina Zhao, Bo Yang, Zhihong Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Gut Microbiome
Osteoarthritis
Lipopolysaccharide
Synovitis
Online Access:https://doi.org/10.1186/s13075-025-03602-y
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https://doi.org/10.1186/s13075-025-03602-y

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