Differences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and Healthy Control Individuals

Differences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and Healthy Control Individuals

Epidemiological, histological, and immunogenetic studies suggest that podoconiosis (a non-infectious tropical lymphoedema affecting approximately 4 million people globally) is an HLA class II-associated inflammatory condition that develops in response to an unknown trigger found in volcanic red clay...

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Bibliographic Details
Main Authors: Mikias Negash, Tigist Girma, Menberework Chanyalew, Dawit H. Alemayehu, Diana Alcantara, Gail Davey, Rosemary J. Boyton, Daniel M. Altmann, Melanie J. Newport, Rawleigh Howe
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Tropical Medicine and Infectious Disease
Subjects:
podoconiosis
non-filarial lymphoedema
pro-inflammatory cytokines
gene expression
mineral stimulation
Online Access:https://www.mdpi.com/2414-6366/9/11/252
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