M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism

M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism

Abstract Impaired autophagy is reported to promote osteoarthritis (OA). However, the mechanism by which autophagy in regulating meniscus degeneration and OA remains unclear. Here, unconvered aberrant energetic metabolism pattern in meniscus cells with OA is uncovered first, which results in lower ad...

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Bibliographic Details
Main Authors: Zongrui Jiang, Chengyun Zhang, Ruonan Liu, Zijing Zhu, Dianbo Long, Xingzhao Wen, Zhijian Yang, Dong Jiang, Guping Mao, Weiming Liao, Zhiqi Zhang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
ATG16L1
autophagy
energetic metabolism
FTO
meniscus degeneration
N6‐methyladenosine
Online Access:https://doi.org/10.1002/advs.202412379
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https://doi.org/10.1002/advs.202412379

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