hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity

hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity

Abstract Compact CRISPR-Cas systems have demonstrated potential for effective packaging into adeno-associated viruses (AAVs) for use in gene therapy. However, their applications are currently limited due to modest gene-editing activity. Here we introduce an engineered compact CRISPR-Cas12f (hpCasMIN...

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Main Authors: Shufeng Ma, Kaitong Liao, Kechen Chen, Tong Cheng, Xiaofeng Yang, Peihan Chen, Sijie Li, Mengrao Li, Xin Zhang, Yanqun Zhang, Tao Huang, Xiaobo Wang, Lanfeng Wang, Ying Lin, Zhili Rong
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60124-6
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https://doi.org/10.1038/s41467-025-60124-6

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