DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to t...

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Main Authors: Deniz Simsek, Erika Brunet, Sunnie Yan-Wai Wong, Sachin Katyal, Yankun Gao, Peter J McKinnon, Jacqueline Lou, Lei Zhang, James Li, Edward J Rebar, Philip D Gregory, Michael C Holmes, Maria Jasin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1002080
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https://doi.org/10.1371/journal.pgen.1002080

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