Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice.

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice.

Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infection the virus utilizes pUL38 to limit Akt phosphorylation and...

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Main Authors: Nicole L Diggins, Andrew H Pham, Jennifer Mitchell, Christopher J Parkins, Luke Slind, Rebekah Turner, Byeong-Jae Lee, Andrew D Yurochko, Patrizia Caposio, Jay A Nelson, Meaghan H Hancock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012285
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https://doi.org/10.1371/journal.ppat.1012285

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