Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo

Abstract We developed an efficient, robust, and broadly applicable system for light-induced protein translation to control the production of proteins of interest and study their function. The method is based on the displacement of a single type of antisense morpholino from RNA by the uncaged guanidi...

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Bibliographic Details
Main Authors: Katsiaryna Tarbashevich, Atanu Ghosh, Arnab Das, Debajyoti Kuilya, Swrajit Nath Sharma, Surajit Sinha, Erez Raz
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58207-5
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