Mathematical mechanistic model representing the cancer immunity cycle under radiation effects

Mathematical mechanistic model representing the cancer immunity cycle under radiation effects

Abstract Combining radiotherapy with immune checkpoint inhibitors is a promising approach to improve the effectiveness of cancer treatment. However, the success rates of these clinical studies are limited. It is essential to determine the optimal irradiation scheme that maximizes the therapeutic eff...

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Main Authors: Taisuke Takayanagi, Koichi Miyazaki, Kana Yamasaki, Takahiro Yamada, Futaro Ebina, Takahiro Kanehira, Yasuhito Onodera, Keiji Kobashi, Hiroshi Taguchi, Koichi Yasuda, Norio Katoh, Takayuki Hashimoto, Hidefumi Aoyama, Hiroki Shirato, Kenji Chamoto
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Immunoradiotherapy
Mechanistic model
Cancer-immune cycle
Effector and exhausted cytotoxic T-lymphocytes
Hypofractionation
Draining lymph node
Online Access:https://doi.org/10.1038/s41598-025-04715-9
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https://doi.org/10.1038/s41598-025-04715-9

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