Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa

Abstract Antibiotic-resistant bacteria could be tackled by identifying trade-offs of evolution, such as high fitness costs, which may be harnessed to force reversion to susceptibility. A decline in antimicrobial resistance can occur through compensatory mutations or by genetic reversion to the wild-...

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Bibliographic Details
Main Authors: Sara Hernando-Amado, Pablo Laborda, Ruggero La Rosa, Søren Molin, Helle Krogh Johansen, José Luis Martínez
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60330-2
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