HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study

HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study

Recurrent opportunistic infections (OIs) in patients with severely immunosuppressed AIDS remain an unresolved medical challenge despite advancements in antiretroviral therapy (ART). To address this gap, we developed an HLA-mismatched allogeneic adoptive immune therapy (AAIT) specifically targeting t...

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Main Authors: Tao Yang, Zhiman Xie, Zhe Xu, Bo Tu, Huan Lu, Huihuang Huang, Lei Huang, Chao Zhang, Liying Gao, Lei Jin, Ping Ma, Jun Zou, Limin Liu, Cheng Zhen, Chunbao Zhou, Sirun Meng, Yuan-Yuan Li, Jin-Wen Song, Shixiong Yang, Hui-Sheng Ai, Yanmei Jiao, Ming Shi, Ruonan Xu, Fu-Sheng Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
AIDS
allogeneic
cell therapy
clinical trail
immune restoration
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2364744
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https://www.tandfonline.com/doi/10.1080/22221751.2024.2364744

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