Optimization of clustering parameters for single-cell RNA analysis using intrinsic goodness metrics

IntroductionThe accurate clustering of cell subpopulations is a crucial aspect of single-cell RNA sequencing. The ability to correctly subdivide cell subpopulations hinges on the efficacy of unsupervised clustering. Despite the advancements and numerous adaptations of clustering algorithms, the corr...

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Bibliographic Details
Main Authors: Nicolina Sciaraffa, Antonino Gagliano, Luigi Augugliaro, Claudia Coronnello
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioinformatics
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Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1562410/full
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