Dissecting the Impact of Genetic Background on Oncogenic Response to Radiation Exposure in the <i>Ptch1</i><sup>+/−</sup> Mouse Model

Dissecting the Impact of Genetic Background on Oncogenic Response to Radiation Exposure in the <i>Ptch1</i><sup>+/−</sup> Mouse Model

Medulloblastoma (MB) is a common primary brain cancer in children. The sonic hedgehog (SHH) pathway is indispensable for the normal development of the cerebellum, and MB is often caused by persistent SHH activation owing to mutations in pathway components. Patched1 (<i>PTCH1</i>) is the...

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Bibliographic Details
Main Authors: Barbara Tanno, Emiliano Fratini, Simona Leonardi, Flavia Novelli, Valentina Pisano, Mariateresa Mancuso, Simonetta Pazzaglia
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
medulloblastoma mouse model
DNA damage
DNA repair
apoptosis
cell cycle
gene expression
Online Access:https://www.mdpi.com/2073-4409/13/22/1912
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