Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

In chemical risk assessment the human relevance of adverse health effects observed in experimental animal studies and the underlying toxicological mechanisms, i.e., adverse outcome pathways is often assumed, unless evidence suggests otherwise. Yet, detailed systematic guidance as to how human releva...

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Bibliographic Details
Main Authors: Annick D. van den Brand, Julia J. Meerman, Christina H. J. Veltman, Mirjam Luijten
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Toxicology
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Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1616817/full
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