HPV16 <em>E6</em> Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway

HPV16 <em>E6</em> Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway

Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses’ oncogenes <i>E6</i> and &l...

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Bibliographic Details
Main Authors: Georgios Konstantopoulos, Danai Leventakou, Despoina-Rozi Saltiel, Efthalia Zervoudi, Eirini Logotheti, Spyros Pettas, Korina Karagianni, Angeliki Daiou, Konstantinos E. Hatzistergos, Dimitra Dafou, Minas Arsenakis, Amanda Psyrri, Christine Kottaridi
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
HPV16
cervical cancer
immune escape
hypoxia
microRNAs
E6
Online Access:https://www.mdpi.com/1999-4915/16/1/113
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https://www.mdpi.com/1999-4915/16/1/113

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