Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens

Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens

Abstract H9N2 avian influenza virus (AIV) is endemic in poultry worldwide and increasingly zoonotic. Despite the long-term widespread use of inactivated vaccines, H9N2 AIVs remain dominant in chicken flocks. We demonstrated that inactivated vaccines did not prevent the replication of H9N2 AIVs in th...

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Main Authors: Zhe Hu, Hui Ai, Zhen Wang, Shiyue Huang, Honglei Sun, Xinxin Xuan, Mingyue Chen, Jinxiu Wang, Wei Yan, Jiayi Sun, Juan Pu, Christopher B. Brooke, Kin-Chow Chang, Yipeng Sun, Jinhua Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01115-y
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https://doi.org/10.1038/s41541-025-01115-y

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