Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer

Abstract The Warburg effect, also known as aerobic glycolysis, plays a crucial role in the onset and progression of colorectal cancer (CRC), although its mechanism remains unclear. In this study, bioinformatics analysis of public databases combined with validation using clinical specimens identified...

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Bibliographic Details
Main Authors: Ruixue Huo, Weihan Li, Hao Wu, Kexin He, Hao Wang, Shan Zhang, Shu-Heng Jiang, Rongkun Li, Junli Xue
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07457-8
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