No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations

No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional...

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Main Authors: Jenna M. Benoit, Jessica A. Breznik, Ying Wu, Allison Kennedy, Li-Min Liu, Braeden Cowbrough, Barbara Baker, Megan Hagerman, Catherine M. Andary, Maha Mushtaha, Nora Abdalla, Jamie D. McNicol, Gail Gauvreau, Paul Y. Kim, Judah A. Denburg, Andrew P. Costa, Darryl P. Leong, Ishac Nazy, MyLinh Duong, Jonathan L. Bramson, Maggie J. Larché, Chris P. Verschoor, Dawn M. E. Bowdish
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60216-3
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https://doi.org/10.1038/s41467-025-60216-3

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