Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients
Aim. To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL). Methods. 185 consecutive CHC patients (14.4% cirrhotics, 70.2%...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/812140 |
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| author | Ioannis S. Elefsiniotis Christos Pavlidis Elena Vezali Theodoros Mariolis-Sapsakos Sotirios Koutsounas George Saroglou |
| author_facet | Ioannis S. Elefsiniotis Christos Pavlidis Elena Vezali Theodoros Mariolis-Sapsakos Sotirios Koutsounas George Saroglou |
| author_sort | Ioannis S. Elefsiniotis |
| collection | DOAJ |
| description | Aim. To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL). Methods. 185 consecutive CHC patients (14.4% cirrhotics, 70.2% prior intravenous drug users) treated with pegylated interferon-a2b plus ribavirin, for 24 or 48 weeks based on viral genotype, were retrospectively analyzed. SVR was confirmed by undetectable serum HCV-RNA six months after the end of treatment schedule.
Results. Thirty percent of CHC/HBsAg-negative patients were anti-HBc-positive. Anti-HBc positivity was more prevalent in cirrhotic, compared to noncirrhotic patients (76.9% versus 19.5%, P<.05). Serum HBV-DNA was detected in the minority of anti-HBc-positive patients (1.97%). Overall, 62.1% of patients exhibited SVR, while 28.6% did not; 71.4% of non-SVRs were infected with genotype 1. In the univariate analysis, the anti-HBc positivity was negatively associated with treatment outcome (P=.065). In the multivariate model, only the advanced stage of liver disease (P=.015) and genotype-1 HCV infection (P=.003), but not anti-HBc-status (P=.726), proved to be independent predictors of non-SVR.
Conclusion. Serum anti-HBc positivity does not affect the SVR rates in treatment-naïve CHC patients with high pretreatment viral load, receiving the currently approved combination treatment. |
| format | Article |
| id | doaj-art-43065c0cd0fe4374b1357b599e4a8384 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-43065c0cd0fe4374b1357b599e4a83842025-02-03T05:48:03ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/812140812140Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C PatientsIoannis S. Elefsiniotis0Christos Pavlidis1Elena Vezali2Theodoros Mariolis-Sapsakos3Sotirios Koutsounas4George Saroglou5University Department of Internal Medicine, Hepatology Unit, “Elena Venizelou” Hospital, 11521 Athens, GreeceReference Center for Viral Hepatitis, I.K.A, Athens, GreeceUniversity Department of Internal Medicine, Hepatology Unit, “Elena Venizelou” Hospital, 11521 Athens, GreeceUniversity Department of Internal Medicine, Hepatology Unit, “Elena Venizelou” Hospital, 11521 Athens, GreeceReference Center for Viral Hepatitis, I.K.A, Athens, GreeceUniversity Department of Internal Medicine, Hepatology Unit, “Elena Venizelou” Hospital, 11521 Athens, GreeceAim. To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL). Methods. 185 consecutive CHC patients (14.4% cirrhotics, 70.2% prior intravenous drug users) treated with pegylated interferon-a2b plus ribavirin, for 24 or 48 weeks based on viral genotype, were retrospectively analyzed. SVR was confirmed by undetectable serum HCV-RNA six months after the end of treatment schedule. Results. Thirty percent of CHC/HBsAg-negative patients were anti-HBc-positive. Anti-HBc positivity was more prevalent in cirrhotic, compared to noncirrhotic patients (76.9% versus 19.5%, P<.05). Serum HBV-DNA was detected in the minority of anti-HBc-positive patients (1.97%). Overall, 62.1% of patients exhibited SVR, while 28.6% did not; 71.4% of non-SVRs were infected with genotype 1. In the univariate analysis, the anti-HBc positivity was negatively associated with treatment outcome (P=.065). In the multivariate model, only the advanced stage of liver disease (P=.015) and genotype-1 HCV infection (P=.003), but not anti-HBc-status (P=.726), proved to be independent predictors of non-SVR. Conclusion. Serum anti-HBc positivity does not affect the SVR rates in treatment-naïve CHC patients with high pretreatment viral load, receiving the currently approved combination treatment.http://dx.doi.org/10.1155/2009/812140 |
| spellingShingle | Ioannis S. Elefsiniotis Christos Pavlidis Elena Vezali Theodoros Mariolis-Sapsakos Sotirios Koutsounas George Saroglou Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients Gastroenterology Research and Practice |
| title | Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients |
| title_full | Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients |
| title_fullStr | Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients |
| title_full_unstemmed | Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients |
| title_short | Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients |
| title_sort | impact of hepatitis b exposure on sustained virological response rates of highly viremic chronic hepatitis c patients |
| url | http://dx.doi.org/10.1155/2009/812140 |
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