Micrometer‐scale tPA beads amplify plasmin generation for enhanced thrombolytic therapy

Abstract Rapid restoration of blood flow is critical in treating acute ischemic stroke. Current thrombolytic therapies using tissue plasminogen activator (tPA) are limited by low recanalization rates and risks of off‐target bleeding. Here, we demonstrate that a remarkably simple adjustment—using mic...

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Bibliographic Details
Main Authors: Matthew J. Osmond, Fabrice Dabertrand, Nidia Quillinan, Enming J. Su, Daniel A. Lawrence, David W. M. Marr, Keith B. Neeves
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Bioengineering & Translational Medicine
Subjects:
Online Access:https://doi.org/10.1002/btm2.70012
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