Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation
<b>Background</b>: Prior studies suggest that patients’ body composition changes following transjugular intrahepatic portosystemic shunt (TIPS) implantation, potentially influencing complications and survival. <b>Method</b>: A prototype artificial intelligence (AI)-based, aut...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/2075-4418/15/11/1440 |
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| author | Laura Büttner Annette Aigner Regina Stegherr Simon Iseke Martin Jonczyk Willie Magnus Lüdemann Timo Alexander Auer Federico Collettini Dirk Schnapauff Maximilian de Bucourt Bernhard Gebauer Dominik Geisel Georg Böning |
| author_facet | Laura Büttner Annette Aigner Regina Stegherr Simon Iseke Martin Jonczyk Willie Magnus Lüdemann Timo Alexander Auer Federico Collettini Dirk Schnapauff Maximilian de Bucourt Bernhard Gebauer Dominik Geisel Georg Böning |
| author_sort | Laura Büttner |
| collection | DOAJ |
| description | <b>Background</b>: Prior studies suggest that patients’ body composition changes following transjugular intrahepatic portosystemic shunt (TIPS) implantation, potentially influencing complications and survival. <b>Method</b>: A prototype artificial intelligence (AI)-based, automated computed tomography (CT) body composition analysis tool was used to assess body composition imaging parameters in pre- and postinterventional scans of TIPS patients: visceral (VAT) and subcutaneous adipose tissue (SAT) areas, psoas muscle area (PMA), and total abdominal muscle area (TAMA). Sarcopenia was defined as a lumbar skeletal muscle index (LSMI) ≤ 38.5 cm<sup>2</sup>/m<sup>2</sup> in women and ≤52.4 cm<sup>2</sup>/m<sup>2</sup> in men. We analyzed longitudinal changes in body composition and investigated the impact of sarcopenia at TIPS implantation on the risk of TIPS thrombosis, hepatic encephalopathy, complications, and death using Cox regression models. <b>Results</b>: No clear trend emerged regarding changes in body composition parameters during postinterventional follow-up. Sarcopenia at TIPS implantation increased the instantaneous risk of postinterventional complications (hazard ratio (HR) 1.67; 95% confidence interval (CI) 0.95–2.93), development of hepatic encephalopathy (HR 1.65; 0.81–3.33), as well as the risk of dying within one year (HR 1.39; 0.66–2.92). <b>Conclusions</b>: CT body composition analysis may help in identifying high-risk patients undergoing TIPS implantation. Sarcopenia was associated with increased mortality and a higher incidence of postinterventional complications, particularly hepatic encephalopathy. |
| format | Article |
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| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-42f0b8dbee7b4152b0f8d23c2d5e35c02025-08-20T03:11:22ZengMDPI AGDiagnostics2075-44182025-06-011511144010.3390/diagnostics15111440Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) ImplantationLaura Büttner0Annette Aigner1Regina Stegherr2Simon Iseke3Martin Jonczyk4Willie Magnus Lüdemann5Timo Alexander Auer6Federico Collettini7Dirk Schnapauff8Maximilian de Bucourt9Bernhard Gebauer10Dominik Geisel11Georg Böning12Department of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyInstitute of Biometry and Clinical Epidemiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyInstitute of Biometry and Clinical Epidemiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany<b>Background</b>: Prior studies suggest that patients’ body composition changes following transjugular intrahepatic portosystemic shunt (TIPS) implantation, potentially influencing complications and survival. <b>Method</b>: A prototype artificial intelligence (AI)-based, automated computed tomography (CT) body composition analysis tool was used to assess body composition imaging parameters in pre- and postinterventional scans of TIPS patients: visceral (VAT) and subcutaneous adipose tissue (SAT) areas, psoas muscle area (PMA), and total abdominal muscle area (TAMA). Sarcopenia was defined as a lumbar skeletal muscle index (LSMI) ≤ 38.5 cm<sup>2</sup>/m<sup>2</sup> in women and ≤52.4 cm<sup>2</sup>/m<sup>2</sup> in men. We analyzed longitudinal changes in body composition and investigated the impact of sarcopenia at TIPS implantation on the risk of TIPS thrombosis, hepatic encephalopathy, complications, and death using Cox regression models. <b>Results</b>: No clear trend emerged regarding changes in body composition parameters during postinterventional follow-up. Sarcopenia at TIPS implantation increased the instantaneous risk of postinterventional complications (hazard ratio (HR) 1.67; 95% confidence interval (CI) 0.95–2.93), development of hepatic encephalopathy (HR 1.65; 0.81–3.33), as well as the risk of dying within one year (HR 1.39; 0.66–2.92). <b>Conclusions</b>: CT body composition analysis may help in identifying high-risk patients undergoing TIPS implantation. Sarcopenia was associated with increased mortality and a higher incidence of postinterventional complications, particularly hepatic encephalopathy.https://www.mdpi.com/2075-4418/15/11/1440body compositioncomputed tomographytransjugular intrahepatic portosystemic shuntsarcopenia |
| spellingShingle | Laura Büttner Annette Aigner Regina Stegherr Simon Iseke Martin Jonczyk Willie Magnus Lüdemann Timo Alexander Auer Federico Collettini Dirk Schnapauff Maximilian de Bucourt Bernhard Gebauer Dominik Geisel Georg Böning Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation Diagnostics body composition computed tomography transjugular intrahepatic portosystemic shunt sarcopenia |
| title | Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation |
| title_full | Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation |
| title_fullStr | Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation |
| title_full_unstemmed | Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation |
| title_short | Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation |
| title_sort | sarcopenia as a risk factor in patients undergoing transjugular intrahepatic portosystemic shunt tips implantation |
| topic | body composition computed tomography transjugular intrahepatic portosystemic shunt sarcopenia |
| url | https://www.mdpi.com/2075-4418/15/11/1440 |
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