Strategies to Promote Resiliency: A Randomized Embedded Multifactorial Adaptative Platform (REMAP) Clinical Trial to Study Interventions to Improve Recovery After Surgery in High-Risk Patients

Strategies to Promote Resiliency: A Randomized Embedded Multifactorial Adaptative Platform (REMAP) Clinical Trial to Study Interventions to Improve Recovery After Surgery in High-Risk Patients

Objective:. In a randomized, embedded, multifactorial, adaptive platform (REMAP) trial, we hypothesized that perioperative metformin would improve postoperative time alive and out of the hospital, defined by 90-day hospital-free days (HFD-90), among nondiabetic aged adults. Background:. As our popul...

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Main Authors: Katherine M. Reitz, MD, MSc, Hasan Nassereldine, MD, Jason Kennedy, MS, Ryan Zeh, MD, Farah Khandwala, MS, Christopher W. Seymour, MD, Melanie Quintana, PhD, Kert Viele, PhD, Michelle Detry, PhD, Alison Morris, MD, Barbara Methe, MD, Brian Zuckerbraun, MD, Timothy D. Girard, MD, Oscar C. Marroquin, MD, Stephen Esper, MD, Jennifer Holder-Murray, MD, Anne B. Newman, MD, MPH, Timothy R. Billiar, MD, Scott Berry, PhD, Derek C. Angus, MD, Matthew D. Neal, MD
Format: Article
Language:English
Published: Wolters Kluwer Health 2025-06-01
Series:Annals of Surgery Open
Online Access:http://journals.lww.com/10.1097/AS9.0000000000000566
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http://journals.lww.com/10.1097/AS9.0000000000000566

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