Heterologous prime-boost vaccination drives stromal activation and adaptive immunity against SARS-CoV-2 variants

Heterologous prime-boost vaccination drives stromal activation and adaptive immunity against SARS-CoV-2 variants

Heterologous vaccination strategies have shown superior efficacy over homologous regimens in clinical studies, but the underlying immunological mechanisms remain incompletely understood. Using a mouse model, we investigated the immune responses induced by heterologous prime-boost vaccination with ad...

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Main Authors: Ji Hyang Jeon, Seongryong Kim, Seo-Yeon Kim, Kwang-Soo Shin, Bongju Park, Soojeong Chang, Chang-Yuil Kang, You-Jin Kim, Jong-Eun Park, Sungsu Youk, Dokeun Kim, Jinah Yeo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
COVID-19
heterologous vaccination
cross immunity
mRNA vaccine
adenoviral vaccine
single cell transcriptional analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597417/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597417/full

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