Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the BladParadigm study)

Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the BladParadigm study)

Introduction Muscle-invasive bladder cancer (MIBC) is an aggressive type of cancer. About 50% of patients will die from the disease within 5 years despite radical treatment. This implies that in many patients, the disease has already spread at the time of radical treatment, even though imaging shows...

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Main Authors: Lambertus ALM Kiemeney, Janneke PC Grutters, Erik J.R.J. van der Hoeven, Janneke P.C. Grutters, Antoine G van der Heijden, Sebastiaan W van Koeverden, Lisa MC van Hoogstraten, Maarten de Rooij, Marloes van der Leest, Arnold Baars, Thierry N. Boellaard, Joost L. Boormans, Lars E.J. Bosboom, Quirijn J.A. van den Bouwhuijsen, Siebren Dijkstra, Cristina E. Firanescu, Jurgen J. Fütterer, Ernst P. van Haarst, Tom J.N. Hermans, Marina C. Hovius, Josephine C.B.M. Huige, Michael D.H. Kortleve, Anneke Kusters, Geert J.L.H. van Leenders, Saskia van der Meer, Richard P. Meijer, Harm H.E. van Melick, Laura S. Mertens, Gerd-Jan Molijn, Rinze Reinhard, Ivo G. Schoots, Petra C.G. Simons, Ruth Smit, Femke Struik, Julie Swillens, Charlotte J Tutein Nolthenius, Jeroen Veltman, Andre N. Vis, Thijn F. de Vocht, Jeanette van Vooren, Frank J. Wessels, Carl J. Wijburg, Dennis de Witte, Monique Arts-Thijssen, Guus Venderbosch
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e100002.full
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