Identification of diagnostic and prognostic genetic alterations in uveal melanoma using RNA sequencing

Identification of diagnostic and prognostic genetic alterations in uveal melanoma using RNA sequencing

Abstract Uveal melanoma is a lethal intraocular tumour, in which the presence of various genetic alterations correlates with the risk of metastatic dissemination and survival. Here, we tested the detectability of all key mutations and chromosomal changes from RNA sequencing data in 80 primary uveal...

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Main Authors: Rogier J. Nell, Mieke Versluis, Davy Cats, Hailiang Mei, Robert M. Verdijk, Wilma G. M. Kroes, Gregorius P. M. Luyten, Martine J. Jager, Pieter A. van der Velden
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Uveal melanoma
Genetic profiling
RNA sequencing
Online Access:https://doi.org/10.1038/s41598-025-90122-z
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https://doi.org/10.1038/s41598-025-90122-z

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